How will it impact our EB-5 process if the main applicant is overseas large part of the year?

He should file and obtain a reentry permit or it may impact all of your ability to stay in the U.S.

Any time someone is outside the U.S. with a green card for more than 6 months, they are subject to being questioned about whether or not they gave up their permanent residence when they return to the U.S. He must be able to prove that he did not abandon his residence here. He could show that he has a house or apartment in the U.S.; has bank account here; has a car here; has family here he intended to return to; etc. If he stays outside the U.S. for more than 1 year, he will automatically lose his green-card status. He should consult his own immigration lawyer about all this.

As long as you timely file your I-829 petition and the principal applicant remains a conditional lawful resident, his extended absence and business problems should not materially affect your case. When you file the petition to remove conditions (I-829) between June and September, you must include evidence that the investment funds have been sustained at risk and the required jobs have been created or will be created within a reasonable period of time.

Doesn''t he have a re-entry permit? If not, he should get one soon to avoid this type of heartburn.

it should be fine. Make sure he applies for a reentry permit if he will be gone longer than a year and continues to pay taxes on worldwide income.

If he does not abandon his residence, there should be no issue. Be sure he does not leave for over six months.