As an EB-5 investor with a pending I-526, what are my chances of successfully obtaining an E-2 visa?

After becoming a citizen of Grenada, you must reside in Grenada for three years before you can use Grenada as your country of citizenship for an E-2 visa application.

The two processes are not entirely incompatible. You can have the present intent of entering the U.S. to pursue your E-2 business, and if and when your EB-5 process is adjudicated, you can depart the U.S. in accordance with your E-2 visa and complete consular processing abroad for your green card. Your E-2 petition must include a statement of your intent to depart the U.S. once your E-2 status has ended and it should also confirm that you are not entering the U.S. to adjust status. All of this being said, the consular officer may ask about your future plans given your pending I-526 petition and you should be prepared to answer these questions.

Sadly, your chances have suddenly changed. Whereas previously the issue was immigrant intent, it appears President Biden will sign a new law very soon. Section 5901 changes eligibility for E visas. Individuals who have acquired citizenship through financial investment must have been domiciled in that country for “a continuous period of not less than 3 years at any point before applying for an E nonimmigrant visa.” If you already had an E-2 visa, you would likely be safe as this residency requirement does not apply to individuals who have previously been granted E nonimmigrant status. This new law will limit use of "Citizenship by Investment" programs of countries, such as Grenada, that have enabled investors who acquire citizenship in a treaty visa country to obtain E-2 nonimmigrant visas while awaiting availability of an immigrant visa.

Unfortunately, Congress just passed a law that requires anyone who got citizenship by investment to be domiciled in the country for at least 3 years before they can be eligible for an E-2 visa. Unless you already applied for the visa, you may have to live in Grenada for a while before getting an E-2.

Check with your immigration attorney. I believe the State Dept. just put a wrinkle in that strategy by requiring 3 years of residence for E eligibility.

Your place of birth is the only place that matters regarding the EB-5 priority date. An E-2 requires proof of nonimmigrant intent. A pending immigrant visa will make that impossible for you to demonstrate.