How can EB-5 funds be invested in different, detached TEAs?

It is possible and would depend on whether it is a direct investment in a holding company wholly owning subsidiaries, or whether it is an indirect/induced job creation through investment in a project within an approved regional center.

In the situation where you are investing into one new commercial enterprise with a portfolio of job creating entities, each job creating entity would need to be in a TEA. It would probably be easier for USCIS to understand your petition if the TEAs were contiguous or at least within a common area.

Personal investment funds can be invested in a holding company. The holding company owns 100 percent of the subsidiaries and each subsidiary is located in different TEAs. The personal investment can be dispersed amongst several businesses in different TEAs.

We would need additional information. It is unclear what you are asking, but if you are asking if you can have several businesses in different TEAS, then you could have your holding company in one TEA where you deposit the investment and hire the employees and then divide the funds among your various business entities.

Yes they can be invested in detached TEAs. How it is done would depend on whether you are investing in a portfolio of regional center projects or direct stand-alone projects.